This document is a press release from the Department of Justice announcing that opioid manufacturer Insys Therapeutics agreed to a $225 million global resolution to settle criminal and civil investigations related to its illegal promotion and marketing of the opioid painkiller Subsys. The settlement includes Insys pleading guilty to five counts of mail fraud and paying $155 million in criminal penalties, as well as $167.4 million to settle civil False Claims Act allegations.